蛋白序列数据

概述

主要内容为蛋白序列数据，包含高质量的、手工注释的非冗余的蛋白质信息，包含蛋白质的基本信息、序列、序列特征、功能、名称和谱系、亚细胞定位、疾病与变异、翻译后修饰、表达、相互作用等信息。≥57万条

数据结构及样例

{
    "数据ID":"2",
    "蛋白检索号": "Q04844",
    "蛋白检索名称": "ACHE_HUMAN",
    "蛋白名称": "Acetylcholine receptor subunit epsilon",
    "物种": "Homo sapiens(Human)",
    "基因名称": "CHRNE",
    "基因别名": "ACHRE",
    "序列长度": "493",
    "注释得分": "5.0",
    "功能": {
        "function": [
            {
                "功能描述": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane",
                "参考文献": [
                    {
                        "来源": "PubMed",
                        "来源id": "27375219"
                    }
                ]
            }
        ]
    },
    "疾病与变异": {
        "疾病": [
            {
                "disease": {
                    "疾病名称": "Myasthenic syndrome, congenital, 4A, slow-channel",
                    "疾病id": "DI-04397",
                    "疾病缩写名": "CMS4A",
                    "疾病描述": "A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS4A is a slow-channel myasthenic syndrome. It is caused by kinetic abnormalities of the AChR, resulting in prolonged AChR channel opening episodes, prolonged endplate currents, and depolarization block. This is associated with calcium overload, which may contribute to subsequent degeneration of the endplate and postsynaptic membrane.",
                    "相关数据库": {
                        "数据库名称": "MIM",
                        "数据库id": "605809"
                    },
                    "证据": [
                        {
                            "来源": "PubMed",
                            "来源id": "12141316"
                        },
                        {
                            "来源": "PubMed",
                            "来源id": "27375219"
                        },
                        {
                            "来源": "PubMed",
                            "来源id": "7531341"
                        },
                        {
                            "来源": "PubMed",
                            "来源id": "7538206"
                        },
                        {
                            "来源": "PubMed",
                            "来源id": "8872460"
                        }
                    ]
                },
                "相关内容": "The disease is caused by variants affecting the gene represented in this entry",
            }
    },
    "序列": {
        "序列描述": {
            "氨基酸序列": "MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFNRVPDLPYAPCIQP",
            "分子量": "54697"
        }
    }
}